Studies continue pursuing a detailed understanding of the mechanisms underlying gene transcription in the intestine and on the developmental regulation of bile acid transporters in the liver. Work focuses on the gene responsible for cystic fibrosis (CFTR), on the mechanisms responsible for transporting bile salts from the intestine back to the liver, and on development of transport mechanisms responsible for jaundice in infants and children. Molecular and cellular biological techniques are being used to understand the mechanisms underlying liver development and cholestatic liver disease.
Clinical investigation continues on children who have undergone liver and intestinal transplantation to define better ways for managing immunosuppression and fighting infection. There has been considerable progress in understanding of psychological problems that develop in children post-organ transplantation.
There is considerable interest in the study of acute liver failure in children and developing better mechanisms for treatment. Mount Sinai has accumulated one of the largest series of patients with this critical disorder in the world and has had excellent success in saving these patients using novel strategies in transplantation, including the use of living donors.
The Division also cares for more than 500 patients with inflammatory bowel disease and has had continued to strive for better methods of treating these illnesses with medication and surgery.